Xeroderma pigmentosum: clues to understanding cancer initiation

• Main Authors: Hamid Reza Rezvani (Author), Frédéric Mazurier (Author), Fanny Morice-Picard (Author), Thomas Jouary (Author), Muriel Cario-André (Author), Cécile Ged (Author), Hubert de Verneuil (Author), Alain Taïeb (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2010-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Xeroderma pigmentosum (XP) type C is a rare autosomal recessive disorder that occurs because of inactivation of the xeroderma pigmentosum group C (XPC) protein, which is an important DNA damage recognition protein involved in DNA nucleotide excision repair (NER). This defect, which prevents removal...