Meropenem Stability in Human Plasma at −20 °C: Detailed Assessment of Degradation

• Main Authors: Matthias Gijsen (Author), Benjamin Filtjens (Author), Pieter Annaert (Author), Yeghig Armoudjian (Author), Yves Debaveye (Author), Joost Wauters (Author), Peter Slaets (Author), Isabel Spriet (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There are concerns about the stability of meropenem in plasma samples, even when frozen at −20 °C. Previous smaller studies suggested significant degradation of meropenem at −20 °C after 3-20 days. However, in several recent clinical studies, meropenem plasma samples were still stored at −20 °C, or...