In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancer

• Main Authors: Chao-Di Chang (Author), Min-Wu Chao (Author), Hsueh-Yun Lee (Author), Yi-Ting Liu (Author), Huang-Ju Tu (Author), Ssu-Ting Lien (Author), Tony Eight Lin (Author), Tzu-Ying Sung (Author), Shih-Chung Yen (Author), Sing-Han Huang (Author), Kai-Cheng Hsu (Author), Shiow-Lin Pan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibiting a specific target in cancer cells and reducing unwanted side effects has become a promising strategy in pancreatic cancer treatment. MAP4K4 is associated with pancreatic cancer development and correlates with poor clinical outcomes. By phosphorylating MKK4, proteins associated with cell a...