QT PRODACT: Usability of Miniature Pigs in Safety Pharmacology Studies: Assessment for Drug-Induced QT Interval Prolongation

To investigate whether miniature pigs are useful for evaluating the potential of drugs for drug-induced prolongation of the QT interval, we performed an in vivo QT assay using conscious and unrestricted miniature pigs. Compared with the vehicle average baseline values, haloperidol at 3 and 10 mg/kg,...

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Main Authors: Mayumi Kano (Author), Tohru Toyoshi (Author), Sakae Iwasaki (Author), Masami Kato (Author), Masayoshi Shimizu (Author), Takao Ota (Author)
Format: Book
Published: Elsevier, 2005-01-01T00:00:00Z.
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3rd Floor Main Library

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