In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren

• Main Authors: Ronald Kong (Author), Jiyuan Ma (Author), Seongwoo Hwang (Author), Young‐Choon Moon (Author), Ellen M. Welch (Author), Marla Weetall (Author), Joseph M. Colacino (Author), Neil Almstead (Author), John Babiak (Author), Elizabeth Goodwin (Author)
• Format: Book
• Published: Wiley, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Ataluren promotes ribosomal readthrough of premature termination codons in mRNA which result from nonsense mutations. In vitro studies were performed to characterize the metabolism and enzyme kinetics of ataluren and its interaction potential with CYP enzymes. Incubation of [14C]‐ataluren w...