Camostat mesilate, a serine protease inhibitor, exerts aquaretic effects and decreases urinary exosomal AQP2 levels

• Main Authors: Yutaka Kakizoe (Author), Terumasa Nakagawa (Author), Yasunobu Iwata (Author), Qinyuan Deng (Author), Masataka Adachi (Author), Yoshikazu Miyasato (Author), Miyuki Nakagawa (Author), Yu Nagayoshi (Author), Kayo Nishiguchi (Author), Yuki Narita (Author), Yuichiro Izumi (Author), Takashige Kuwabara (Author), Kimio Tomita (Author), Kenichiro Kitamura (Author), Masashi Mukoyama (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Serine proteases (SPs) play physiological roles in the kidney. We previously reported that a synthetic SP inhibitor, camostat mesilate (CM), suppressed sodium reabsorption in the renal tubule and showed natriuretic effects in aldosterone-infused rats. Here, we aimed to explore novel physiological ro...