Nrf2-Heme oxygenase-1 modulates autophagy and inhibits apoptosis triggered by elevated glucose levels in renal tubule cells

• Main Authors: Joo-Heon Kim (Author), Kyeong Min Kim (Author), Jin Uk Jeong (Author), Jong Ho Shin (Author), Jae Min Shin (Author), Ki Tae Bang (Author)
• Format: Book
• Published: The Korean Society of Nephrology, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background : Autophagy is a highly balanced process in which lysosomes remove aged and damaged organelles and cellular proteins. Autophagy is essential to maintain homeostasis in the kidneys. Methods : Using human renal tubule cells HK-2, we assessed the impact of high glucose (HG) on autophagy. We...