Monitoring of complex forming of the active pharmaceutical substance and β-cyclodextrin as an additive of the mobile phase using mass spectrometry

• Main Authors: Milenković Anđela (Author), Miljić Dragana (Author), Mitrović Jelena (Author), Protić Ana (Author), Otašević Biljana (Author)
• Format: Book
• Published: Pharmaceutical Association of Serbia, Belgrade, Serbia, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In recent years, there is aim to reduce toxic solvents use in chromatographic techniques. Beta-cyclodextrins (β-CD) are commonly used for this purpose, as substance retention modulators. By increasing their concentration in the mobile phase, generally there is a decrease in analyte retention time, a...