Dual-targeting inhibition of TNFR1 for alleviating rheumatoid arthritis by a novel composite nucleic acid nanodrug

• Hoofdauteurs: Xiaonan Wang (Auteur), Fanfan Guo (Auteur), Yi Zhang (Auteur), Ziyi Wang (Auteur), Jiaqi Wang (Auteur), Rongrong Luo (Auteur), Xiao Chu (Auteur), Yongxing Zhao (Auteur), Pengchao Sun (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2023-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Selective suppression of tumor necrosis factor (TNF) α-TNF receptor 1 (TNFR1) signaling is a potent solution for rheumatoid arthritis (RA). Herein, novel composite nucleic acid nanodrugs that simultaneously restrain TNF α binding and TNFR1 multimerization were designed to reinforce inhibition of TNF...