Dual-targeting inhibition of TNFR1 for alleviating rheumatoid arthritis by a novel composite nucleic acid nanodrug

• Main Authors: Xiaonan Wang (Author), Fanfan Guo (Author), Yi Zhang (Author), Ziyi Wang (Author), Jiaqi Wang (Author), Rongrong Luo (Author), Xiao Chu (Author), Yongxing Zhao (Author), Pengchao Sun (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Selective suppression of tumor necrosis factor (TNF) α-TNF receptor 1 (TNFR1) signaling is a potent solution for rheumatoid arthritis (RA). Herein, novel composite nucleic acid nanodrugs that simultaneously restrain TNF α binding and TNFR1 multimerization were designed to reinforce inhibition of TNF...