Genetic manipulation of Leishmania donovani threonyl tRNA synthetase facilitates its exploration as a potential therapeutic target.

• Main Authors: Sanya Chadha (Author), Ramachandran Vijayan (Author), Sakshi Gupta (Author), Manoj Munde (Author), Samudrala Gourinath (Author), Rentala Madhubala (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aminoacyl tRNA synthetases are central enzymes required for protein synthesis. These enzymes are the known drug targets in bacteria and fungi. Here, we for the first time report the functional characterization of threonyl tRNA synthetase (LdThrRS) of Leishmania donovani, a protozoan parasite, the pr...