Inhibition of histone deacetylase (HDAC) by 4-phenylbutyrate results in increased junctional conductance between rat corpora smooth muscle cells.

• Hoofdauteurs: Hong Zhan Wang (Auteur), Barbara eRosati (Auteur), Chris eGordon (Auteur), Virginijus eValiunas (Auteur), David eMcKinnon (Auteur), Ira S Cohen (Auteur), Peter R Brink (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2015-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

4-phenylbutyrate (4-PB) has been shown to increase the protein content in a number of cells types. One such protein is Connexin43 (Cx43). We show here that 4-phenylbutyrate exposure results in significantly elevated cell to cell coupling, as determined by dual whole cell patch clamp. Incubation with...