Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade

• Main Authors: Young Yun Jung (Author), Jong Hyun Lee (Author), Dongwoo Nam (Author), Acharan S. Narula (Author), Ojas A. Namjoshi (Author), Bruce E. Blough (Author), Jae-Young Um (Author), Gautam Sethi (Author), Kwang Seok Ahn (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Because of the essential role of signal transducer and activator of transcription 3 (STAT3) in proliferation, anti-apoptosis, and chemoresistance of multiple myeloma (MM), we investigated whether icariin, a prenylated flavonol glycoside, inhibits both constitutive and inducible STAT3 activation in h...