Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade

• Autors principals: Young Yun Jung (Autor), Jong Hyun Lee (Autor), Dongwoo Nam (Autor), Acharan S. Narula (Autor), Ojas A. Namjoshi (Autor), Bruce E. Blough (Autor), Jae-Young Um (Autor), Gautam Sethi (Autor), Kwang Seok Ahn (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Because of the essential role of signal transducer and activator of transcription 3 (STAT3) in proliferation, anti-apoptosis, and chemoresistance of multiple myeloma (MM), we investigated whether icariin, a prenylated flavonol glycoside, inhibits both constitutive and inducible STAT3 activation in h...