Population pharmacokinetic modeling of molibresib and its active metabolites in patients with solid tumors: A semimechanistic autoinduction model

• Main Authors: Anu Shilpa Krishnatry (Author), Alexander Voelkner (Author), Arindam Dhar (Author), Marita Prohn (Author), Geraldine Ferron‐Brady (Author)
• 格式: 圖書
• 出版: Wiley, 2021-07-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Abstract Molibresib (GSK525762) is an investigational, orally bioavailable, small‐molecule bromodomain and extraterminal (BET) protein inhibitor for the treatment of advanced solid tumors. Molibresib was initially evaluated in a first‐time‐in‐human (FTIH) study BET115521 consisting of two parts: Par...