In vitro metabolic profile and drug‐drug interaction assessment of secnidazole, a high‐dose 5‐nitroimidazole antibiotic for the treatment of bacterial vaginosis

• Main Authors: Helen S. Pentikis (Author), Nikki Adetoro (Author), Gregory Kaufman (Author)
• פורמט: ספר
• יצא לאור: Wiley, 2020-08-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Abstract A single‐dose oral granule formulation of secnidazole 2 g (SOLOSEC™) has been approved in the US as a treatment for bacterial vaginosis. Available data on the likelihood of in vitro drug‐drug and alcohol‐drug interactions are limited. Secnidazole was incubated with cultured human hepatocyte...