SCH00013, a Novel Ca2+ Sensitizer With Positive Inotropic and No Chronotropic Action in Heart Failure

SCH00013, a Novel Ca2+ Sensitizer With Positive Inotropic and No Chronotropic Action in Heart Failure

We investigated the effects of the agent SCH00013 on Ca2+-induced force generation in rabbit skinned cardiac muscle fibers and in vivo cardiac function in high-pacing-induced heart failure dogs. The Ca2+-induced force generation in skinned cardiac muscle fibers was determined at pH 6.2 - 7.4, and SC...

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Main Authors: Naoto Tadano (Author), Sachio Morimoto (Author), Akira Yoshimura (Author), Makoto Miura (Author), Kimitomo Yoshioka (Author), Mitsuo Sakato (Author), Iwao Ohtsuki (Author), Yoshikazu Miwa (Author), Fumi Takahashi-Yanaga (Author), Toshiyuki Sasaguri (Author)
Format: Book
Published: Elsevier, 2005-01-01T00:00:00Z.
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