SCH00013, a Novel Ca2+ Sensitizer With Positive Inotropic and No Chronotropic Action in Heart Failure
We investigated the effects of the agent SCH00013 on Ca2+-induced force generation in rabbit skinned cardiac muscle fibers and in vivo cardiac function in high-pacing-induced heart failure dogs. The Ca2+-induced force generation in skinned cardiac muscle fibers was determined at pH 6.2 - 7.4, and SC...
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Elsevier,
2005-01-01T00:00:00Z.
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| 001 | doaj_ef03b378013c4bc18d1eabe6fd8d5ecf | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Naoto Tadano |e author |
| 700 | 1 | 0 | |a Sachio Morimoto |e author |
| 700 | 1 | 0 | |a Akira Yoshimura |e author |
| 700 | 1 | 0 | |a Makoto Miura |e author |
| 700 | 1 | 0 | |a Kimitomo Yoshioka |e author |
| 700 | 1 | 0 | |a Mitsuo Sakato |e author |
| 700 | 1 | 0 | |a Iwao Ohtsuki |e author |
| 700 | 1 | 0 | |a Yoshikazu Miwa |e author |
| 700 | 1 | 0 | |a Fumi Takahashi-Yanaga |e author |
| 700 | 1 | 0 | |a Toshiyuki Sasaguri |e author |
| 245 | 0 | 0 | |a SCH00013, a Novel Ca2+ Sensitizer With Positive Inotropic and No Chronotropic Action in Heart Failure |
| 260 | |b Elsevier, |c 2005-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.fp0040654 | ||
| 520 | |a We investigated the effects of the agent SCH00013 on Ca2+-induced force generation in rabbit skinned cardiac muscle fibers and in vivo cardiac function in high-pacing-induced heart failure dogs. The Ca2+-induced force generation in skinned cardiac muscle fibers was determined at pH 6.2 - 7.4, and SCH00013 was found to have a significant Ca2+ sensitizing effect at pH 7.2 to 7.4. There was no significant difference in the Ca2+ sensitizing action between the enantiomers of SCH00013. The Ca2+ sensitizing effect of SCH00013 was dependent on the sarcomere length, being significant only at a long sarcomere length. SCH00013 elicited a positive inotropic effect at more than 0.3 and 1 mg/kg, i.v. in normal and heart failure dogs, respectively, with no chronotropic action. These results strongly suggested that SCH00013 is a novel Ca2+ sensitizer that elicits a positive inotropic and no chronotropic effect in heart failure, probably through enhancing the Frank-Starling mechanism. Keywords:: Ca2+ sensitizer, skinned cardiac muscle fiber, sarcomere length, high-pacing, Frank-Starling mechanism | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 97, Iss 1, Pp 53-60 (2005) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319322935 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ef03b378013c4bc18d1eabe6fd8d5ecf |z Connect to this object online. |