Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity

• Main Authors: Islam Zaki (Author), Amal M. Y. Moustafa (Author), Botros Y. Beshay (Author), Reham E. Masoud (Author), Mohammed A. I. Elbastawesy (Author), Mohammed A. S. Abourehab (Author), Mohamed Y. Zakaria (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new series of vinyl amide-, imidazolone-, and triazinone-linked combretastatin A-4 analogues have been designed and synthesised. These compounds have been evaluated for their cytotoxic activity against MDA-MB-231 breast cancer cells. The triazinone-linked combretastatin analogues (6 and 12) exhibi...