Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

• প্রধান লেখক: Miriam Cnop (Author), Sanna Toivonen (Author), Mariana Igoillo-Esteve (Author), Paraskevi Salpea (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2017-09-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Background: Pancreatic β cell dysfunction and death are central in the pathogenesis of most if not all forms of diabetes. Understanding the molecular mechanisms underlying β cell failure is important to develop β cell protective approaches. Scope of review: Here we review the role of endoplasmic ret...