Acryl-3,5-bis(2,4-difluorobenzylidene)-4-piperidone targeting cellular JUN proto-oncogene, AP-1 transcription factor subunit inhibits head and neck squamous cell carcinoma progression

• Main Authors: Levi Arnold (Author), Juan Pineda Gomez (Author), Michael Barry (Author), Marrion Yap (Author), Laura Jackson (Author), Thuc Ly (Author), David Standing (Author), Subhash B. Padhye (Author), Bernhard Biersack (Author), Shrikant Anant (Author), Sufi Mary Thomas (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide with a survival rate below fifty percent. Addressing meager therapeutic options, a series of small molecule inhibitors were screened for antitumor efficacy. The most potent analog, acryl-3,5-bis(2,4-difluo...