Longitudinal micro-CT provides biomarkers of lung disease that can be used to assess the effect of therapy in preclinical mouse models, and reveal compensatory changes in lung volume

• Main Authors: Greetje Vande Velde (Author), Jennifer Poelmans (Author), Ellen De Langhe (Author), Amy Hillen (Author), Jeroen Vanoirbeek (Author), Uwe Himmelreich (Author), Rik J. Lories (Author)
• Format: Book
• Published: The Company of Biologists, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In vivo lung micro-computed tomography (micro-CT) is being increasingly embraced in pulmonary research because it provides longitudinal information on dynamic disease processes in a field in which ex vivo assessment of experimental disease models is still the gold standard. To optimize the quantitat...