Dietary Iron Overload and <i>Hfe^−/−</i> Related Hemochromatosis Alter Hepatic Mitochondrial Function

• Main Authors: Christine Fischer (Author), Chiara Volani (Author), Timea Komlódi (Author), Markus Seifert (Author), Egon Demetz (Author), Lara Valente de Souza (Author), Kristina Auer (Author), Verena Petzer (Author), Laura von Raffay (Author), Patrizia Moser (Author), Erich Gnaiger (Author), Guenter Weiss (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Iron is an essential co-factor for many cellular metabolic processes, and mitochondria are main sites of utilization. Iron accumulation promotes production of reactive oxygen species (ROS) via the catalytic activity of iron species. Herein, we investigated the consequences of dietary and genetic iro...