Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia

• Main Authors: Anfal Al-Mass (Author), Pegah Poursharifi (Author), Marie-Line Peyot (Author), Roxane Lussier (Author), Isabelle Chenier (Author), Yat Hei Leung (Author), Anindya Ghosh (Author), Abel Oppong (Author), Elite Possik (Author), Yves Mugabo (Author), Rasheed Ahmad (Author), Robert Sladek (Author), S.R. Murthy Madiraju (Author), Fahd Al-Mulla (Author), Marc Prentki (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glycerol-3-phosphate (Gro3P) phosphatase (G3PP) hydrolyzes Gro3P to glycerol that exits the cell, thereby operating a "glycerol shunt", a metabolic pathway that we identified recently in mammalian cells. We have investigated the role of G3PP and the glycerol shunt in the regulat...