A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs

• Principais autores: Wouter J. Venema (Autor), Sanne Hiddingh (Autor), Jorg van Loosdregt (Autor), John Bowes (Autor), Brunilda Balliu (Autor), Joke H. de Boer (Autor), Jeannette Ossewaarde-van Norel (Autor), Susan D. Thompson (Autor), Carl D. Langefeld (Autor), Aafke de Ligt (Autor), Lars T. van der Veken (Autor), Peter H.L. Krijger (Autor), Wouter de Laat (Autor), Jonas J.W. Kuiper (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2024-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Summary: Single-nucleotide polymorphisms (SNPs) near the ERAP2 gene are associated with various autoimmune conditions, as well as protection against lethal infections. Due to high linkage disequilibrium, numerous trait-associated SNPs are correlated with ERAP2 expression; however, their functional m...