Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1

• 主要な著者: Jing Zhang (著者), Qiu-Sha Pan (著者), Xing-Kai Qian (著者), Xiang-Lu Zhou (著者), Ya-Jie Wang (著者), Rong-Jing He (著者), Le-Tian Wang (著者), Yan-Ran Li (著者), Hong Huo (著者), Cheng-Gong Sun (著者), Lei Sun (著者), Li-Wei Zou (著者), Ling Yang (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Pancreatic lipase (PL) is a well-known key target for the prevention and treatment of obesity. Human carboxylesterase 1A (hCES1A) has become an important target for the treatment of hyperlipidaemia. Thus, the discovery of potent dual-target inhibitors based on PL and hCES1A hold great potential for...