Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1

• Ngā kaituhi matua: Jing Zhang (Author), Qiu-Sha Pan (Author), Xing-Kai Qian (Author), Xiang-Lu Zhou (Author), Ya-Jie Wang (Author), Rong-Jing He (Author), Le-Tian Wang (Author), Yan-Ran Li (Author), Hong Huo (Author), Cheng-Gong Sun (Author), Lei Sun (Author), Li-Wei Zou (Author), Ling Yang (Author)
• Hōputu: Pukapuka
• I whakaputaina: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Pancreatic lipase (PL) is a well-known key target for the prevention and treatment of obesity. Human carboxylesterase 1A (hCES1A) has become an important target for the treatment of hyperlipidaemia. Thus, the discovery of potent dual-target inhibitors based on PL and hCES1A hold great potential for...