Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy

Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy

Protein neddylation is catalyzed by a three-enzyme cascade, namely an E1 NEDD8-activating enzyme (NAE), one of two E2 NEDD8 conjugation enzymes and one of several E3 NEDD8 ligases. The physiological substrates of neddylation are the family members of cullin, the scaffold component of cullin RING lig...

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Main Authors: Yanan Li (Author), Chaorong Wang (Author), Tiantian Xu (Author), Peichen Pan (Author), Qing Yu (Author), Lei Xu (Author), Xiufang Xiong (Author), Tingjun Hou (Author), Sunliang Cui (Author), Yi Sun (Author)
Format: Book
Published: Elsevier, 2021-11-01T00:00:00Z.
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