Discovery of a Novel Nav1.7 Inhibitor From Cyriopagopus albostriatus Venom With Potent Analgesic Efficacy

• Váldodahkkit: Yunxiao Zhang (Dahkki), Dezheng Peng (Dahkki), Biao Huang (Dahkki), Qiuchu Yang (Dahkki), Qingfeng Zhang (Dahkki), Minzhi Chen (Dahkki), Mingqiang Rong (Dahkki), Zhonghua Liu (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Spider venoms contain a vast array of bioactive peptides targeting ion channels. A large number of peptides have high potency and selectivity toward sodium channels. Nav1.7 contributes to action potential generation and propagation and participates in pain signaling pathway. In this study, we descri...