Discovery of a Novel Nav1.7 Inhibitor From Cyriopagopus albostriatus Venom With Potent Analgesic Efficacy

• প্রধান লেখক: Yunxiao Zhang (লেখক), Dezheng Peng (লেখক), Biao Huang (লেখক), Qiuchu Yang (লেখক), Qingfeng Zhang (লেখক), Minzhi Chen (লেখক), Mingqiang Rong (লেখক), Zhonghua Liu (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Spider venoms contain a vast array of bioactive peptides targeting ion channels. A large number of peptides have high potency and selectivity toward sodium channels. Nav1.7 contributes to action potential generation and propagation and participates in pain signaling pathway. In this study, we descri...