N-Palmitoylethanolamine Maintains Local Lipid Homeostasis to Relieve Sleep Deprivation-Induced Dry Eye Syndrome

• Main Authors: Qi Chen (Author), Chunyan Ji (Author), Ruihe Zheng (Author), Longhe Yang (Author), Jie Ren (Author), Yitian Li (Author), Yun Han (Author), Pan Zhou (Author), Zuguo Liu (Author), Yan Qiu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sleep loss is a key factor associated with dry eye. Use of a "stick over water" mouse model revealed that sleep deprivation induces accumulation of lipids, hypertrophy, and dysfunction of the lacrimal gland. These changes result in decreased tear production and dry eye clinical signs. The...