Nafamostat Mesilate Is an Extremely Potent Inhibitor of Human Tryptase

• Main Authors: Shuji Mori (Author), Yoshinori Itoh (Author), Ryoko Shinohata (Author), Toshiaki Sendo (Author), Ryozo Oishi (Author), Masahiro Nishibori (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previously, nafamostat mesilate was found to be a potent inhibitor of human tryptase. In present study, we performed a kinetic study to determine its Ki value for tryptase and compared it with that of gabexate mesilate. Nafamostat mesilate inhibited human tryptase in a competitive manner. The appare...