Efficient Gene Editing for Heart Disease via ELIP-Based CRISPR Delivery System

• Main Authors: Xing Yin (Author), Romain Harmancey (Author), Brion Frierson (Author), Jean G. Wu (Author), Melanie R. Moody (Author), David D. McPherson (Author), Shao-Ling Huang (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liposomes as carriers for CRISPR/Cas9 complexes represent an attractive approach for cardiovascular gene therapy. A critical barrier to this approach remains the efficient delivery of CRISPR-based genetic materials into cardiomyocytes. Echogenic liposomes (ELIP) containing a fluorescein isothiocyana...