An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias

• Main Authors: Cristina Mirantes (Author), Núria Eritja (Author), Maria Alba Dosil (Author), Maria Santacana (Author), Judit Pallares (Author), Sónia Gatius (Author), Laura Bergadà (Author), Oscar Maiques (Author), Xavier Matias-Guiu (Author), Xavier Dolcet (Author)
• Format: Book
• Published: The Company of Biologists, 2013-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. The role of PTEN in carcinogenesis has been validated by knockout mouse models. PTEN heterozygous mice develop neoplasms in multiple organs. Unfortunately, the embryonic lethality of biallelic excision of PTE...