High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.

• Main Authors: Nathalie Aulner (Author), Anne Danckaert (Author), Eline Rouault-Hardoin (Author), Julie Desrivot (Author), Olivier Helynck (Author), Pierre-Henri Commere (Author), Hélène Munier-Lehmann (Author), Gerald F Späth (Author), Spencer L Shorte (Author), Geneviève Milon (Author), Eric Prina (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND/OBJECTIVES: Human leishmaniases are parasitic diseases causing severe morbidity and mortality. No vaccine is available and numerous factors limit the use of current therapies. There is thus an urgent need for innovative initiatives to identify new chemotypes displaying selective activity...