NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation

• Main Authors: Yamada Toshihiko (Author), Zuo Daiying (Author), Yamamoto Tatsuo (Author), Olszewski Rafal T (Author), Bzdega Tomasz (Author), Moffett John R (Author), Neale Joseph H (Author)
• Format: Book
• Published: SAGE Publishing, 2012-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Metabotropic glutamate receptors (mGluRs) have been identified as significant analgesic targets. Systemic treatments with inhibitors of the enzymes that inactivate the peptide transmitter N-acetylaspartylglutamate (NAAG), an mGluR3 a...