Hit Identification and Functional Validation of Novel Dual Inhibitors of HDAC8 and Tubulin Identified by Combining Docking and Molecular Dynamics Simulations

• Main Authors: Antonio Curcio (Author), Roberta Rocca (Author), Federica Chiera (Author), Maria Eugenia Gallo Cantafio (Author), Ilenia Valentino (Author), Ludovica Ganino (Author), Pierpaolo Murfone (Author), Angela De Simone (Author), Giulia Di Napoli (Author), Stefano Alcaro (Author), Nicola Amodio (Author), Anna Artese (Author)
• Format: Book
• Published: MDPI AG, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chromatin organization, which is under the control of histone deacetylases (HDACs), is frequently deregulated in cancer cells. Amongst HDACs, HDAC8 plays an oncogenic role in different neoplasias by acting on both histone and non-histone substrates. Promising anti-cancer strategies have exploited du...