PK/PD analysis of trazodone and gabapentin in neuropathic pain rodent models: Translational PK‐PD modeling from nonclinical to clinical development

• Main Authors: Laura Oggianu (Author), Beatrice Garrone (Author), Francesco Fiorentini (Author), Francesca Del Bene (Author), Maria Teresa Rosignoli (Author), Francesco Paolo Di Giorgio (Author), Rafal Marian Kaminski (Author)
• Format: Book
• Published: Wiley, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract A pharmacokinetic/pharmacodynamic (PK/PD) model was developed to describe the time course of writhings after intraperitoneal injection of acetic acid in mice. The model was applied to investigate the antinociceptive effect of trazodone and gabapentin alone and in combination. Writhings time...