Biological Evaluation in Resistant Cancer Cells and Study of Mechanism of Action of Arylvinyl-1,2,4-Trioxanes

• Main Authors: Jerome P. L. Ng (Author), Mohit K. Tiwari (Author), Ali Adnan Nasim (Author), Rui Long Zhang (Author), Yuanqing Qu (Author), Richa Sharma (Author), Betty Yuen Kwan Law (Author), Dharmendra K. Yadav (Author), Sandeep Chaudhary (Author), Paolo Coghi (Author), Vincent Kam Wai Wong (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

1,2,4-trioxane is a pharmacophore, which possesses a wide spectrum of biological activities, including anticancer effects. In this study, the cytotoxic effect and anticancer mechanism of action of a set of 10 selected peroxides were investigated on five phenotypically different cancer cell lines (A5...