Systemically Administered Ligands of Toll-Like Receptor 2, -4, and -9 Induce Distinct Inflammatory Responses in the Murine Lung

• Príomhchruthaitheoirí: H. Ehrentraut (Údar), R. Meyer (Údar), M. Schwederski (Údar), S. Ehrentraut (Údar), M. Velten (Údar), C. Grohé (Údar), P. Knuefermann (Údar), G. Baumgarten (Údar), O. Boehm (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Hindawi Limited, 2011-01-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Objective. To determine whether systemically administered TLR ligands differentially modulate pulmonary inflammation. Methods. Equipotent doses of LPS (20 mg/kg), CpG-ODN (1668-thioat 1 nmol/g), or LTA (15 mg/kg) were determined via TNF activity assay. C57BL/6 mice were challenged intraperitoneally....