NADPH Oxidase 5 (NOX5) Overexpression Promotes Endothelial Dysfunction via Cell Apoptosis, Migration, and Metabolic Alterations in Human Brain Microvascular Endothelial Cells (hCMEC/D3)

• Main Authors: Javier Marqués (Author), Joaquín Fernández-Irigoyen (Author), Elena Ainzúa (Author), María Martínez-Azcona (Author), Adriana Cortés (Author), Carmen Roncal (Author), Josune Orbe (Author), Enrique Santamaría (Author), Guillermo Zalba (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NADPH oxidases (NOX) constitute the main reactive oxygen species (ROS) source in blood vessels. An oxidative stress situation due to ROS overproduction can lead into endothelial dysfunction, a molecular mechanism that precedes cardiovascular diseases (CVDs) such as atherosclerosis, myocardial infarc...