Liquid chromatography-tandem mass spectrometry method for simultaneous determination of valproic acid and its ene-metabolites in epilepsy patient plasma

• Váldodahkkit: Huan Lu (Dahkki), Chong Su (Dahkki), Lei Yin (Dahkki), Liqiang Gu (Dahkki), Jingkai Gu (Dahkki), Xiaohui Chen (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2016-04-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

A simple and high throughput method was developed and validated for simultaneous determination of valproic acid and its two toxicant ene-metabolites, 2-enevalproic acid and 4-enevalproic acid in epilepsy patient plasma using liquid chromatography-tandem mass spectrometry. Probenecid was used as inte...