Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy

• Main Authors: Sara El Ashkar (Author), Dominique Van Looveren (Author), Franziska Schenk (Author), Lenard S. Vranckx (Author), Jonas Demeulemeester (Author), Jan De Rijck (Author), Zeger Debyser (Author), Ute Modlich (Author), Rik Gijsbers (Author)
• Format: Book
• Published: Elsevier, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Retroviral vectors have shown their curative potential in clinical trials correcting monogenetic disorders. However, therapeutic benefits were compromised due to vector-induced dysregulation of cellular genes and leukemia development in a subset of patients. Bromodomain and extraterminal domain (BET...