Toxoplasma infection in male mice alters dopamine-sensitive behaviors and host gene expression patterns associated with neuropsychiatric disease.

• Main Authors: Graham L Cromar (Author), Jonathan R Epp (Author), Ana Popovic (Author), Yusing Gu (Author), Violet Ha (Author), Brandon J Walters (Author), James St Pierre (Author), Xuejian Xiong (Author), John G Howland (Author), Sheena A Josselyn (Author), Paul W Frankland (Author), John Parkinson (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During chronic infection, the single celled parasite, Toxoplasma gondii, can migrate to the brain where it has been associated with altered dopamine function and the capacity to modulate host behavior, increasing risk of neurocognitive disorders. Here we explore alterations in dopamine-related behav...