Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK

• Main Authors: Fangzhou Guo (Author), Guoyuan Ling (Author), Jianting Qiu (Author), Jicheng Li (Author), Yu Gan (Author), YingYing Yu (Author), Jiamei Tang (Author), Ligen Mo (Author), Haozhe Piao (Author)
• Format: Book
• Published: BMC, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ferroptosis, a non-apoptotic form of cell death induced by accumulation of free iron ions and lipid peroxidation, its importance for cancer treatment is gradually being recognized. Research on the anti-cancer mechanism of juglone is accumulating. However, the specific mechanism b...