How to manage KRAS G12C-mutated advanced non-small-cell lung cancer

• Main Authors: Biagio Ricciuti (Author), Alessia Mira (Author), Elisa Andrini (Author), Pietro Scaparone (Author), Sandra Vietti Michelina (Author), Federica Pecci (Author), Luca Cantini (Author), Andrea De Giglio (Author), Giuseppe Lamberti (Author), Chiara Ambrogio (Author), Giulio Metro (Author)
• Format: Book
• Published: BioExcel Publishing Ltd, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Constitutive KRAS signalling drives tumorigenesis across several cancer types. In non-small-cell lung cancer (NSCLC) activating KRAS mutations occur in ~30% of cases, and the glycine to cysteine substitution at codon 12 (G12C) is the most common KRAS alteration. Although KRAS mutations have been con...