Impact of single-nucleotide variants and individual characteristics on adverse events of L-asparaginase in children with acute lymphoblastic leukemia

• Main Authors: Jesús Alonso Gándara-Mireles (Author), Ismael Lares-Asseff (Author), Elio Aarón Reyes Espinoza (Author), Verónica Loera Castañeda (Author), Lourdes Patricia Córdova Hurtado (Author), Flor de María Reyes Gutiérrez (Author), Antonio Sandoval-Cabrera (Author), Ignacio Villanueva Fierro (Author), Julio Cesar Grijalva Ávila (Author), Claudia Castro Arreola (Author), Leslie Patrón-Romero (Author), Horacio Almanza Reyes (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionL-Asparaginase (L-Asp) is a key drug in the treatment of acute lymphoblastic leukemia (ALL); however, it is commonly associated with the occurrence of adverse events (AE). Risk factors such as age, sex, nutritional status, and some single nucleotide variants (SNVs) in specific genes coul...