Bisbenzylisoquinoline Alkaloids of Cissampelos Sympodialis With in Vitro Antiviral Activity Against Zika Virus

• Egile Nagusiak: Poliana Gomes da Silva (Egilea), Aventino H. Fonseca (Egilea), Malu P. Ribeiro (Egilea), Taizia D. Silva (Egilea), Cristiane F. F. Grael (Egilea), Lindomar J. Pena (Egilea), Tania M. S. Silva (Egilea), Eduardo de Jesus Oliveira (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

In search of new antiviral compounds against Zika virus we conducted a bioassay-guided fractionation of bisbenzyilisoquinoline alkaloids isolated from Cissampelos sympodialis (Menispermaceae), a medicinal plant species endemic to Brazil. Six subfractions were obtained from a tertiary alkaloidal frac...