Simultaneous determination of doxorubicin and its dipeptide prodrug in mice plasma by HPLC with fluorescence detection

• Váldodahkkit: Jing Han (Dahkki), Jue Zhang (Dahkki), Haiyan Zhao (Dahkki), Yan Li (Dahkki), Zilin Chen (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2016-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

A simple and sensitive high performance liquid chromatography with fluorescence detection (HPLC-FD) has been developed for simultaneous quantification of doxorubicin (DOX) and its dipeptide conjugate prodrug (PDOX) in mice plasma. The chromatographic separation was carried out on an Amethyst C18-H c...