Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis

• Main Authors: Lynda Aoudjehane (Author), Jérémie Gautheron (Author), Wilfried Le Goff (Author), Claire Goumard (Author), Julia Gilaizeau (Author), Chan Sonavine Nget (Author), Eric Savier (Author), Muhammad Atif (Author), Philippe Lesnik (Author), Romain Morichon (Author), Yves Chrétien (Author), Yvon Calmus (Author), Olivier Scatton (Author), Chantal Housset (Author), Filomena Conti (Author)
• Format: Book
• Published: The Company of Biologists, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Normothermic perfusion provides a means to rescue steatotic liver grafts, including by pharmacological defatting. In this study, we tested the potential of new drug combinations to trigger defatting in three human culture models, primary hepatocytes with induced steatosis, primary hepatocytes isolat...