Mechanochemical preparation of triptolide-loaded self-micelle solid dispersion with enhanced oral bioavailability and improved anti-tumor activity

• Main Authors: Dabu Zhu (Author), Qiuqin Zhang (Author), Yifang Chen (Author), Minghua Xie (Author), Jianbo Li (Author), Shen Yao (Author), Ming Li (Author), Zhao Lou (Author), Yue Cai (Author), Xuanrong Sun (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triptolide (TP), a compound isolated from a Chinese medicinal herb, possesses potent anti-tumor, immunosuppressive, and anti-inflammatory properties, but was clinically limited due to its poor solubility, bioavailability, and toxicity. Considering the environment-friendly, low-cost mechanochemical t...