Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms

• Main Authors: Promsuk Jutabha (Author), Naohiko Anzai (Author), Toru Kimura (Author), Atsuo Taniguchi (Author), Wako Urano (Author), Hisashi Yamanaka (Author), Hitoshi Endou (Author), Hiroyuki Sakurai (Author)
• פורמט: ספר
• יצא לאור: Elsevier, 2011-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

We analyzed the functional properties of five nonsynonymous single nucleotide polymorphisms (SNPs) in the sodium-phosphate transporter NPT4 gene (SLC17A3) using the Xenopus oocyte expression system. NPT4 variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of [14C]para-aminohippu...