Effect of Repeated Administration of ɣ-Valerolactone (GVL) and GHB in the Mouse: Neuroadaptive Changes of the GHB and GABAergic System

• Main Authors: Paolo Frisoni (Author), Giorgia Corli (Author), Sabrine Bilel (Author), Micaela Tirri (Author), Laura Camilla Gasparini (Author), Letizia Alfieri (Author), Margherita Neri (Author), Fabio De-Giorgio (Author), Matteo Marti (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Gamma-hydroxybutyric acid (GHB) at low dosages has anxiolytic effects and promotes REM sleep and low-wave deep sleep. In the U.S., the legal form of GHB is prescribed to adults suffering from narcolepsy-associated cataplexy; the sodium salt of GHB is reserved for alcohol-addiction treatm...