Design and synthesis of triazolopyridine derivatives as potent JAK/HDAC dual inhibitors with broad-spectrum antiproliferative activity

• Главные авторы: Zhengshui Xu (Автор), Changchun Ye (Автор), Xingjie Wang (Автор), Ranran Kong (Автор), Zilu Chen (Автор), Jing Shi (Автор), Xin Chen (Автор), Shiyuan Liu (Автор)
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• Опубликовано: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Предметы: article
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A series of triazolopyridine-based dual JAK/HDAC inhibitors were rationally designed and synthesised by merging different pharmacophores into one molecule. All triazolopyridine derivatives exhibited potent inhibitory activities against both targets and the best compound 4-(((5-(benzo[d][1, 3]dioxol-...